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Folicular Dendritic Cell Secreted Protein (FDC-SP) and related peptides to treat Immunoglobulin A Nephropathy (IGAN)
IgA
nephropathy (IgAN), also known as Berger disease, is the most common cause of
chronic … moreIgA
nephropathy (IgAN), also known as Berger disease, is the most common cause of
chronic glomerulonephritis and leads to end stage kidney failure in about 25%
of cases. Twenty to forty percent of IgAN
patients receiving kidney transplants suffer disease recurrence within 5 years
of transplant.
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Primary:
University of Manitoba
Date posted:
Jan 23, 2012
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Proportional Assist Ventilation+
Respiratory
diseases impair the function of the lungs and/or the muscles of breathing. When … moreRespiratory
diseases impair the function of the lungs and/or the muscles of breathing. When
the disease becomes severe the patient may become unable to maintain adequate
ventilation (Respiratory failure). Such patients are placed on ventilators,
which assist their breathing until the disease improves.
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Primary:
University of Manitoba
Date posted:
Jan 23, 2012
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SEMAPHORIN 3E protein as a biomarker and a potential biologic treatment for asthma
Asthma is associated with bronchial
constriction and airway “remodeling” due to changes in bronchial smooth … moreAsthma is associated with bronchial
constriction and airway “remodeling” due to changes in bronchial smooth muscle.
Besides changes in epithelial cells and
vascularization, key characteristic
structural changes involve smooth muscle hypertrophy and hyperplasia. Dr. Soussi-Gounni has discovered that a signal
protein of the SEMAPHORIN family
suppresses proliferation, migration and contractility in airway smooth muscle
cells (ASMs). This protein and its
receptors are present in normal tissue and it is depleted in biopsies from
asthmatic patients. Dr. Soussi Gounni
went on to demonstrate that the protein could successfully reduce
allergen-induced asthma symptoms in a mouse model. less
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Primary:
University of Manitoba
Date posted:
Dec 9, 2011
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Neuro Mechano Stimulator Motorized
It is hypothesize that simultaneous stimulation of two neural circuits, the properioceptors and the mechanoreceptors … moreIt is hypothesize that simultaneous stimulation of two neural circuits, the properioceptors and the mechanoreceptors, would result in faster recovery for patients with partial spinal cord injury (ASIA A and B). In another word, the technology is with the goal of creating neuroplasticity at the spinal cord level, in which the device will help the generation of new path ways of a partially damaged nerve. The device would be helpful particularly for Paraplegia, babinski reflex positive.
The technology is based on the stimulation of the mechanoreceptors in order to illicit the reflex pathways with movement as opposed to muscular stimulation. less
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Primary:
University of Manitoba
Date posted:
Apr 27, 2011
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Using RNAi target sequence of different gene silencing potency in regulating protein expression and functional properties of dendritic cells
RNA interference (RNAi) is a cellular process that involves multiple RNA-protein interactions. Its gene silencing activity … moreRNA interference (RNAi) is a cellular process that involves multiple RNA-protein interactions. Its gene silencing activity is activated when a double-stranded RNA (dsRNA) molecule of greater than 19 duplex nucleotides enters the cells, causing degradation of both the dsRNA and single stranded RNA (endogenous mRNA) of identical sequences. Others and we have selected the most potent RNAi sequence for efficient gene silencing of target genes in specific cell types. As the sequence encoded in the dsRNA contributes to the potency of the dsRNA in degradation of target mRNA, we reasoned also that the choice of shRNA target sequences in the lentiviral vector system will also allow us to regulate different levels of surface expression of a costimulatory molecule stably and reproducibly. less
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Primary:
University of Manitoba
Date posted:
Apr 7, 2011
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Compounds and compositions having anti-viral activity
Acquired immune deficiency syndrome (AIDS) is a slow degenerative disease of the immune and nervous systems … moreAcquired immune deficiency syndrome (AIDS) is a slow degenerative disease of the immune and nervous systems resulting from HIV-1 infection. This infectious disease has shown the potential to threaten the lives, welfare, and social stability of the world. Even though the progress in the field of anti-HIV-1 chemotherapy in the past decade has been dramatic, the efficient protection against HIV-1 infection still remains one of the most important challenges. The complete blockage of AIDS progression with current chemotherapy appears to be difficult due to a rapid occurrence of viral drug-resistance. Hence, in addition to develop an efficient AIDS vaccine, the finding of new anti-HIV molecules with specific targets and the low toxicity becomes an urgent priority as a part of the global strategy of controlling the spread of the HIV infection. less
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Primary:
University of Manitoba
Date posted:
Feb 28, 2011
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Integrated computational approach to increase imaging depth in swept-source optical coherence tomography by the simultaneous use of ultrasound
There’s anecdotal evidence that the simultaneous use of ultrasound could reduce the negative effect of … moreThere’s anecdotal evidence that the simultaneous use of ultrasound could reduce the negative effect of multiple light scattering in optical coherence tomography (OCT) imaging. Our invention puts this ad-hoc idea on a firm theoretical and computational ground. Our results would allow us to build a “next generation” optical coherence tomography system, one that simultaneously uses ultrasound to almost double the current imaging depth.imaging depth in swept-source optical coherence tomography by the simultaneous use of ultrasound. less
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Primary:
University of Manitoba
Date posted:
Feb 28, 2011
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iRNA inhibition of influenza infection
In the past, researchers have identified genes involved in influenza infection, with a focus on genes … moreIn the past, researchers have identified genes involved in influenza infection, with a focus on genes which inhibit viral replication. The present invention relates to genes involved in cellular resistance and survival of infection. Dr. Coombs used Global Phenotypic Mapping strategies to identify 5 major and 35 minor genes involved in cell survival, and they showed that specific iRNAs are protective. They also demonstrated that cell survival and viral replication are partially independent. This provides a potential therapeutic and preventative treatment for influenza. less
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Primary:
University of Manitoba
Date posted:
Feb 28, 2011
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Novel Tracheotomy tube design to prevent intra-tracheal granulation tissue development
Tracheotomy is a common surgical procedure that creates an airway through an incision in the neck … moreTracheotomy is a common surgical procedure that creates an airway through an incision in the neck into the trachea. Approximately 200 tracheotomies are performed per year in Winnipeg with a total of 1200-1500 tracheotomy tubes being used every year. less
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Primary:
University of Manitoba
Date posted:
Dec 14, 2010
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Crude Canolol extract from oilseeds and plants using heated systems
The extraction of “canolol” a potent antioxidant and anti-inflammatory product primarily from canola seeds and meal … moreThe extraction of “canolol” a potent antioxidant and anti-inflammatory product primarily from canola seeds and meal is crucial to value addition to canola. less
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Primary:
University of Manitoba
Date posted:
Dec 14, 2010
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